Research

Topic 3

Sports and Exercise Medicine Lab.

Increasing number of patients with dementia and cognitive impairment has a direct impact on daily living and quality of life, resulting in burdens for society and family. Mild cognitive impairment (MCI) is characterized by cognitive impairment such as memory loss in daily living. MCI is associated with increased risks of developing dementia and mortality. Therefore, interventions that promote early detection and prevention of cognitive impairment and dementia are required.

Handgrip strength was strongly associated with the risk of MCI in a Korean elderly population.
Moreover, greater handgrip strength was associated with higher cognitive function in cognitively normal elderly subjects.

The risk of cognitive dysfunction significantly and linearly increased according to muscle strength status independent of potential confounding factors.
Using stratified analyses, a significant association between muscle strength status and risk of cognitive impairment was observed in those with low physical activity, but not those with high physical activity.
Handgrip strength is associated with increased risk of new-onset cognitive dysfunction over 6 years of follow-up in cognitively healthy middle aged and older adults at baseline

Dynapenia and lower muscle strength were associated with an increased risk of mild cognitive impairment (MCI) over time
Persistent and newly diagnosed dynapenia were associated with an increased risk of MCI, while improved dynapenia was not associated with an increased risk of MCI
The early detection and prevention of dynapenia may prevent age-related cognitive decline

Multidimensional sleep characteristics ─ quantity, continuity, regularity, and timing ─ were associated with a high risk of dementia, whereas higher physical activity levels were associated with a lower risk of dementia.
The combination of optimal sleep patterns and engagement in physical activity showed a synergistic association with a reduced risk of dementia.
High levels of physical activity attenuated the adverse associations of short sleep duration and low sleep continuity on dementia incidence but did not mitigate the effects of irregular sleep or advanced sleep timing.
Healthy sleep patterns alone were not associated with reduced dementia risk in the absence of participating in physical activity, highlighting the importance of maintaining both behaviors in older adults.